Differential infection of receptor-modified host cells by receptor-specific influenza viruses
Identifieur interne : 002445 ( Main/Exploration ); précédent : 002444; suivant : 002446Differential infection of receptor-modified host cells by receptor-specific influenza viruses
Auteurs : Susan M. Carroll [États-Unis] ; James C. Paulson [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 1985.
English descriptors
- Teeft :
- Academic press, Adsorption, Amino, Amino acids, Avian, Binding properties, Biol, Bovine serum albumin, Cell lysates, Cell surface receptors, Chem, Confluent monolayers, Control cells, Determinant, Erythrocyte, Glycoprotein, Hemagglutinin, Hemagglutinins, Host cells, Immunoprecipitation, Influenza, Influenza virus, Influenza viruses, Inhibitor, Linkage, Lysates, Mdck, Mdck cells, Monolayers, Native cells, Native erythrocytes, Native mdck cells, Neuraminidase, Neuraminidase activity, Parent virus, Paulson, Progeny, Progeny virus, Receptor, Receptor determinants, Receptor specificity, Receptor variants, Resialylated, Resialylated cells, Resialylated erythrocytes, Resialylated mdck cells, Second passage, Selective pressure, Sialic, Sialic acid, Sialidase, Sialyloligosaccharide, Sialyltransferase, Tamm, Viral, Viral neuraminidase activity, Virology, Virus.
Abstract
Abstract: Influenza viruses of contrasting receptor specificity have been examined for their ability to infect receptor-modified MDCK cells containing sialyloligosaccharide receptor determinants of defined sequence. Cells were treated with sialidase to remove sialic acid and render them resistant to infection and were then incubated with sialyltransferase and CMP-sialic acid to restore sialic acid in the SAα2,6Gal or SAα2,3Gal linkages. The viruses A/RI/5 +/57 and A/duck/Ukraine/1/63, previously shown to exhibit preferential binding of SAα2,6Gal and SAα2,3Gal linkages, respectively, were found to exhibit differential infection of the receptor-modified cells in accord with their receptor specificity. Coinfection of SAα2,3Gal derivatized cells with a mixture of the two viruses resulted in selective propagation of the SAα2,3Gal-specific A/duck/Ukraine/1/63 virus. The results demonstrate the potential for cell surface receptors to mediate selection of receptor-specific variants of influenza virus.
Url:
DOI: 10.1016/0168-1702(85)90006-1
Affiliations:
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Carroll</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90024</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Paulson, James C" sort="Paulson, James C" uniqKey="Paulson J" first="James C." last="Paulson">James C. Paulson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90024</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Virus Research</title><title level="j" type="abbrev">VIRUS</title><idno type="ISSN">0168-1702</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="165">165</biblScope><biblScope unit="page" to="179">179</biblScope></imprint><idno type="ISSN">0168-1702</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0168-1702</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Adsorption</term><term>Amino</term><term>Amino acids</term><term>Avian</term><term>Binding properties</term><term>Biol</term><term>Bovine serum albumin</term><term>Cell lysates</term><term>Cell surface receptors</term><term>Chem</term><term>Confluent monolayers</term><term>Control cells</term><term>Determinant</term><term>Erythrocyte</term><term>Glycoprotein</term><term>Hemagglutinin</term><term>Hemagglutinins</term><term>Host cells</term><term>Immunoprecipitation</term><term>Influenza</term><term>Influenza virus</term><term>Influenza viruses</term><term>Inhibitor</term><term>Linkage</term><term>Lysates</term><term>Mdck</term><term>Mdck cells</term><term>Monolayers</term><term>Native cells</term><term>Native erythrocytes</term><term>Native mdck cells</term><term>Neuraminidase</term><term>Neuraminidase activity</term><term>Parent virus</term><term>Paulson</term><term>Progeny</term><term>Progeny virus</term><term>Receptor</term><term>Receptor determinants</term><term>Receptor specificity</term><term>Receptor variants</term><term>Resialylated</term><term>Resialylated cells</term><term>Resialylated erythrocytes</term><term>Resialylated mdck cells</term><term>Second passage</term><term>Selective pressure</term><term>Sialic</term><term>Sialic acid</term><term>Sialidase</term><term>Sialyloligosaccharide</term><term>Sialyltransferase</term><term>Tamm</term><term>Viral</term><term>Viral neuraminidase activity</term><term>Virology</term><term>Virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Influenza viruses of contrasting receptor specificity have been examined for their ability to infect receptor-modified MDCK cells containing sialyloligosaccharide receptor determinants of defined sequence. Cells were treated with sialidase to remove sialic acid and render them resistant to infection and were then incubated with sialyltransferase and CMP-sialic acid to restore sialic acid in the SAα2,6Gal or SAα2,3Gal linkages. The viruses A/RI/5 +/57 and A/duck/Ukraine/1/63, previously shown to exhibit preferential binding of SAα2,6Gal and SAα2,3Gal linkages, respectively, were found to exhibit differential infection of the receptor-modified cells in accord with their receptor specificity. Coinfection of SAα2,3Gal derivatized cells with a mixture of the two viruses resulted in selective propagation of the SAα2,3Gal-specific A/duck/Ukraine/1/63 virus. The results demonstrate the potential for cell surface receptors to mediate selection of receptor-specific variants of influenza virus.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Carroll, Susan M" sort="Carroll, Susan M" uniqKey="Carroll S" first="Susan M." last="Carroll">Susan M. Carroll</name></region><name sortKey="Paulson, James C" sort="Paulson, James C" uniqKey="Paulson J" first="James C." last="Paulson">James C. Paulson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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